After Zhang Qian's return, Emperor Wudi of the Han Dynasty sent an emissant to explore a communication route through Rome to Bactria without going through Xiongnu, but without success. Later, the Han army defeated the Xiongnu and gained the Hexi Corridor, opening up the channel between the Western Han Dynasty and the Western Regions. After Huo Qubing defeated Xiongnu in the Qilian Mountains, Zhang Qian suggested contacting Wusun, a powerful country in the Western Regions, to break the right arm of Xiongnu. In the fourth year of the Yuan Dynasty (119 BC), Zhang Qian again went on a mission to the Western Regions, with the purpose of attracting Wusun back to Hexi and communicating with other countries in the Western Regions. Zhang qian to the sun, failed to reach the purpose, in yuan ding two years (before 115) returned to chang 'an, an angel with black sun was Zhang Qianpa to agreement of the other countries also returned home. Wu sun angel to see the big fellow man and all the rich thick, back home after return to black sun gradually close contacts with the big fellow, and after several years, summer Zhang Qiantong make, from then on, the western han dynasty and northwestern states began to frequent contacts, zhangqian forced the western regions, the silk road, the official opening, the emperor in the military for its bo hou.
In the sixteenth year of Yongping (73), Ban Chao accompanied the General Dou Gu to attack the Northern Xiongnu and was ordered to go to the Western Regions. He led 36 officials to Shanshan and conquered it with the determination of "nothing ventured, nothing gained". He then persuaded Khotan to join the central government. Ban Chao re-opened the Silk Road, which had been isolated for 58 years, and helped the countries in the Western regions get rid of the control of Xiongnu. He was appointed as the capital protector of the Western Regions in the Eastern Han Dynasty. Ban Chao operated in the Western Regions for 30 years, strengthening the ties between the Western Regions and the mainland.
In the third year of Yongyuan (91), the northern provinces of Qiuci, Gumo and Wenshu were all annexed to the Eastern Han Dynasty, and Ban Chao set up the Western Regions garrison in Qiuci and took the seat of the Northern Province himself. And ordered the long history of the West Region Xu Qian Tun Shule, echoing the north road.